Seal Biosciences

RasGRP1 is a potential biomarker for stratifying anti-EGFR therapy response in colorectal cancer Oghenekevwe M. Gbenedio, … , Jeroen P. Roose, Philippe Depeille CI Insight. 2019;4(15):e127552. https://doi.org/10.1172/jci.insight.127552 Colorectal cancer (CRC) is the third most frequent neoplastic disorder and is a main cause of tumor-related mortality, as many patients progress to stage IV metastatic CRC. Standard…

September 2020 – Seal Biosciences receives Notice of Publication for patent application 16/878,973 entiltled “Prognostic and Diagnostic Methods for Colorectal Cancer” April 2020 – Seal Biosciences successfully executes limited fundraising round December 2019 – Roose lab at UCSF generates new RasGRP1 antibodies August 2019 – JCI Insight publication supporting value of RasGRP1 as prognostic marker…

RasGRP1 opposes proliferative EGFR–SOS1–Ras signals and restricts intestinal epithelial cell growth Philippe Depeille1,6, Linda M. Henricks1,5, Robert A. H. van de Ven1,5, Ed Lemmens1,5, Chih-Yang Wang1,2, Mary Matli3, Zena Werb1, Kevin M. Haigis4, David Donner3, Robert Warren3 and Jeroen P. Roose1,6 The character of EGFR signals can influence cell fate but mechanistic insights into intestinal…

JOURNAL CELL CYCLE VOL 14, 2015 – Issue 20 Flavors of EGFR-Ras signals impacting intestinal homeostasis Philippe Depeille & Jeroen P Roose The intestine is a highly dynamic organ with continuous renewal of the epithelial cell layer. The small intestine can be subdivided into the duodenum, the jejunum, and the ileum where villi and crypts…

Unexpected insights for anti-EGFR cancer therapy Philippe Depeille, Robert S. Warren and Jeroen P. Roose Colorectal cancer (CRC) is a major cause of morbidity and mortality. It accounts for over 9% of all malignancies, making it the third most common cancer worldwide and second most common cause of death in the developed world. Treatment of…

Regulation of Ras exchange factors and cellular localization of Ras activation by lipid messengers inT cells Jesse E. Jun1, Ignacio Rubio2 and Jeroen P. Roose1* The Ras-MAPK signaling pathway is highly conserved throughout evolution and is activated downstream of a wide range of receptor stimuli. Ras guanine nucleotide exchange factors (RasGEFs) catalyze GTP loading of…

FRONTIER BIOLOGY, 2013, 8 (5) RasGRP Ras guanine nucleotide exchange factors in cancer Olga KSIONDA, Andre LIMNANDER, Jeroen P. ROOSE Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA Abstract RasGRP proteins are activators of Ras and other related small GTPases by the virtue of functioning as guanine nucleotide exchange factors…