JOURNAL CELL CYCLE VOL 14, 2015 – Issue 20

Flavors of EGFR-Ras signals impacting intestinal homeostasis

Philippe Depeille & Jeroen P Roose

The intestine is a highly dynamic organ with continuous renewal of the epithelial cell layer. The small intestine can be subdivided into the duodenum, the jejunum, and the ileum where villi and crypts are found (Fig. 1) whereas only crypts are present in colon. In the crypts self-renewal of stem cells and production of progeny occurs under the influence of Wnt signaling

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