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Frontiers in Immunology

  • September 4, 2013
150 150 Seal Biosciences

Regulation of Ras exchange factors and cellular localization of Ras activation by lipid messengers inT cells

Jesse E. Jun1, Ignacio Rubio2 and Jeroen P. Roose1*

The Ras-MAPK signaling pathway is highly conserved throughout evolution and is activated downstream of a wide range of receptor stimuli. Ras guanine nucleotide exchange factors (RasGEFs) catalyze GTP loading of Ras and play a pivotal role in regulating receptorligand induced Ras activity. In T cells, three families of functionally important RasGEFs are expressed: RasGRF, RasGRP, and Son of Sevenless (SOS)-family GEFs.

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