Regulation of Ras exchange factors and cellular localization of Ras activation by lipid messengers inT cells
Jesse E. Jun1, Ignacio Rubio2 and Jeroen P. Roose1*
The Ras-MAPK signaling pathway is highly conserved throughout evolution and is activated downstream of a wide range of receptor stimuli. Ras guanine nucleotide exchange factors (RasGEFs) catalyze GTP loading of Ras and play a pivotal role in regulating receptorligand induced Ras activity. In T cells, three families of functionally important RasGEFs are expressed: RasGRF, RasGRP, and Son of Sevenless (SOS)-family GEFs.